螺栓连接大变形梁非线性振动特性的实验研究

柔性机械臂、大型可展开天线等机械结构的动作精度受运动过程中大变形几何非线性和连接处接触非线性的影响十分显著。以含螺栓连接结构的大变形梁作为研究对象，针对动力学建模和振动特性开展了实验研究，通过数值计算验证了实验发现的非线性振动特性。搭建了含螺栓连接柔性大变形梁的实验台架，开展了敲击和正弦激振的实验测试。实验结果表明，螺栓连接的柔性梁较连续梁的（无螺栓连接）模态频率降低，阻尼增加，反映出随着激励能量增大，模态频率降低的非线性模态特征。改变螺栓连接位置会显著影响结构的模态频率，其变化规律可由求解线性矩阵特征值定性反映。     

青藏铁路含保温夹层路基厚度与地温关系的研究

通过对青藏铁路风火山段含有保温夹层的路基建立均匀介质分层纯导热模型并运用分层近似解法求出冻土表层的温度函数,结合Lachenbruch给出的冻土层的理论温度表达式,得到了路基填料层、保温层、地表年平均温度与正弦变化温度的振幅比三者之间的隐式方程,并应用该方程对三者之间的关系进行了分析.     

含砂雾封层在桥面铺装工程中的应用

结合含砂雾封层在国道205桥面铺装上的应用,深入分析了含砂雾封层的防水、防老化作用机理,本文系统总结了国道205桥面雾封层施工质量的控制要点,并对施工前后封层各项性能指标进行跟踪检测,分析结果表明采取含砂雾封层措施确实能对桥面早期微裂缝进行有效封水,延缓桥面病害的发生,延长沥青路面的使用寿命。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

适用于混沌密钥分发的新误码协调方法

对于现有的密钥分发中的误码协调方法的复杂性和多次传输的问题，使用倒三角类坐标定位法来解决。将所得裸钥放置于下三角矩阵中，三边分别进行奇偶比较并互相传输计算结果，以达到定位错误比特位的目的。使用互注入光反馈激光器产生相关性高的混沌态来提取裸钥，通过该协调方法，最终可以达到10－8～10－10量级的误码率。通过该方法可以简单、有效地删除裸钥中的误码，满足现实通信对误码率的容忍度。     

A Forward Selection Method on Customer Credit

In this paper, we discuss a selection and evaluation method of customer credit for the commercial bank loans operation, and put forth a forward selection model by optimization techniques. At last, we also give an example to analyze its application.     

论知识经济条件下图书馆效益的提高

阐明了知识经济条件下图书馆效益可大致用知识的使用状况即文献借阅率、网页点击率、咨询解答率和知识创新率来表示。从知识运动的角度，分析了影响图书馆效益的主要因素。并探讨了提高图书馆效益的有效途径。     

环境法的需求与供给——一个法经济学视角

环境法是环境与资源要素相对价格提高、科技发展、人们对良好环境形成偏好条件下的产物。它的供给要受到所在国家利益格局、社会科学知识的积累、法律供给传统等诸要素的影响。在完善一个国家的环境法时，必须充分调动这些因素，以形成可持续发展。     

常规电教媒体的现状及对策

常规电教媒体在我国的教育教学改革过程中曾经发挥过积极的作用。随着科技的进步与发展，常规电教媒体日渐被冷落、遗忘；但常规电教媒体的优势仍然存在，只要采取相应的对策，常规电教媒体在我国教育事业的发展过程中仍可发挥出巨大的作用。     

过滤机液位控制系统在洗煤厂的应用

介绍了过滤机液位控制系统的结构、功能及其在洗煤厂的应用情况，并根据其运行结果，指出了需改进的部分。